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The following medicines increase the level of Lanoxin in the bloodwhich can increase the risk of toxicity:
Drugs such as gentamicintetracyclineranolazineRanexaverapamilCalanVerelanVerelan PMIsoptinIsoptin SRCovera-HSquinidineQuinagluteQuinideamiodaroneCordaroneindomethacinIndocinIndocin-SRalprazolamXanaxXanax XRNiravamspironolactoneAldactoneand itraconazoleSporanoxcan increase digoxin levels and the risk of toxicityThe co-administration of digoxin and beta-blockersfor example propranololInderalInderal LAor calcium channel blockers or CCBsfor exampleverapamilwhich also reduce heart ratecan cause serious heart rate slowingDiuretic-inducedfor exampleby furosemideLasixreduction in blood potassium or magnesium levels may predispose patients to digoxin-induced abnormal heart rhythmsSaquinavirInviraseand ritonavirNorvirincrease the amount of digoxin in the body and may cause digoxin toxicityMirabegronMybetriqincreases digoxin blood levelsThe lowest dose of digoxin should be used if by people who are also using mirabegronOmeprazolePrilosecand other drugs that reduce stomach acidity may increase blood levels of digoxin.
Though this medication is used to treat a certain type of irregular heartbeatit may rarely cause other types of irregular heartbeatsTell your doctor right away if you notice any unusually fast/slow/irregular heartbeat.
Decreased Cardiac Output in Patients With Preserved Left Ventricular Systolic Function.
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