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After opioid detoxificationpatients are likely to have reduced tolerance to opioidsAs the blockade of exogenous opioids provided by REVIA wanes and eventually dissipates completelypatients who have been treated with REVIA may respond to lower doses of opioids than previously usedjust as they would shortly after completing detoxification.
REVIA has fewif anyintrinsic actions besides its opioid blocking propertiesHoweverit does produce some pupillary constrictionby an unknown mechanism.
REVIA has been shown to produce complete blockade of the Purchase artane classification euphoric effects of opioids in both volunteer and addict populationsWhen administered by means that enforce complianceit will produce an effective opioid blockadebut has not been shown to affect the use of cocaine or other non-opioid drugs of abuse.
When coadministered with morphineon a chronic basisREVIA blocks the physical dependence to morphineheroin and other opioids.
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