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The Women’s Health InitiativeWHIestrogen-alone substudy reported increased risks of stroke and deep vein thrombosisDVTin postmenopausal women with daily oral conjugated estrogensCEaloneThe WHI estrogen-plus-progestin substudy reported increased risks of DVTpulmonary embolismstrokeand myocardial infarction in postmenopausal women with daily oral CE combined with medroxyprogesterone acetateMPAIn the absence of comparable datathese risks should be assumed to be similar for other dosage forms of estrogens.
Circulating estrogens modulate the pituitary secretion of the gonadotropinsluteinizing hormoneLHand follicle-stimulating hormoneFSHthrough a negative feedback mechanismEstrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.
This product contains FD&C Yellow No5tartrazinewhich may cause Sildalis cost allergic-type reactionsincluding bronchial asthmain certain susceptible personsAlthough the overall incidence of FD&C Yellow No5tartrazinesensitivity in the general population is lowit is frequently seen in patients who also have aspirin hypersensitivity.
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