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For treating cancerDose should be titrated based on individual patient responseCapsules should be swallowed wholeHydroxyurea capsules should be handled with extreme care and disposed of properly because it causes cell damage.

Acute mucocutaneous toxicity has been reported in patients receiving hydroxyurea at dosages several times the therapeutic doseSorenessviolet erythemaedema on palms and soles followed by scaling of hands and feetsevere generalized hyperpigmentation of the skinand stomatitis have also been observed.

Store this medication at room temperature in the original containerIf a caregiver prepares your dose for youthey should wear gloves or pour the pills directly from their container into the capa small cupor directly into your handThey should avoid touching the pillsThey should always wash their hands before and after giving you the medicationPregnant or nursing women should not prepare the dose for youAsk your oncology team where to return any unused medication for disposalDo not flush down the toilet or throw in the trash.

To decrease the risk of contactadvise caregivers to wear disposable gloves when handling HYDREA or bottles containing HYDREAWash hands with soap and water before and after contact with the bottle or capsules when handling HYDREADo not open HYDREA capsulesAvoid exposure to crushed or opened capsulesIf contact with crushed or opened capsules occurs on the skinwash affected area immediately and thoroughly with soap and waterIf contact with crushed or opened capsules occurs on the eye(sthe affected area should be flushed thoroughly with water or isotonic eyewash designated for that purpose for at least 15 minutesIf the powder from the capsule is spilledimmediately wipe it up with a damp disposable towel and discard in a closed containersuch as a plastic bagas should the empty capsulesThe spill areas should then be cleaned three times using a detergent solution followed by clean waterKeep the medication away from children and petsContact your doctor for instructions on how to dispose of outdated capsules.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofkidney diseaseliver diseaseblood/bone marrow disorderssuch as bone marrow suppressionneutropeniathrombocytopeniaanemiaHIV infectionhigh uric acid level in the bloodradiation treatment.

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