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Absorption of nicotine over 24 hours varies by a factor of two between different individualshowever within-individual variability is small indicating consistent performance of the transdermal system.
Polycyclic aromatic hydrocarbons in tobacco smoke induce the metabolism of drugs catalysed by CYP 1A2and possibly by CYP 1A1When a smoker stopsthis may result in slower metabolism and a consequent rise in blood levels of such drugs.
The Nicotinell patches are used to help you stop smoking as part of an overall treatment programmeWhen you apply the patch to your skinnicotine passes through your skin and into your bodyThe Nicotinell patch programme involves up to 3 stepseach with a different patch sizeAs your body adjusts to not smokingyou should gradually reduce the dose of Nicotinell over a period of up to a maximum of 12 weeks until you no longer need to use the patches.
Our suggestion tool can help you decide if combination therapy is right for youproviding you information on each treatment option.
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